Absorption Technology

Life Factor Research recognizes that applying absorption technology is not a “one size fits all” solution for all ingredients and products containing multiple compounds.

The science of absorption and bioavailability can be complex.  For example the physicochemical properties (chemical structure, solubility, lipophilicity, etc.)  of any nutraceutical formulation must be considered to achieve optimal bioavailability.  Most nutraceuticals are extracted from the natural plant sources and are presented as the crystalline or amorphous powders with high melting points and different water solubilities. Other nutraceuticals such as CLAs and ω‐3/ω‐6 PUFAs are liquid, lipophilic, and water‐insoluble substances. Nutraceuticals are consumed both as the supplements in tablet, capsule, powder and even syrup form.  Molecular weight and the chemical structure of nutraceuticals affect bioavailability parameters such as solubility, lipophilicity, and permeability.

This in turn, influences the bio-accessibility and absorption in the epithelial cells of the intestinal tract.  High bioavailability is the result of a compromise between the solubility and the lipophilicity of biomolecules.  Lipophilic biomolecules have a poor solubility in the GI tract and fluids have a low bio-accessibility.

Hydrophilic biomolecules have a high solubility but are more difficult to pass through the lipophilic bilayer of epithelial cells.  Therefore, some bioactive compounds end up having high solubility but poor cell membrane permeability (e.g., epigallocatechin‐3‐gallate and vitamin C), others have a low solubility and a low cell membrane permeability such as curcumin.  Some possess low solubility but high cell membrane permeability such as resveratrol.  An important example showing the relationship between the structure and the bioavailability is polyphenols. They are found in different plants either in the form of polymers (e.g., proanthocyanidins) or in a glycosylated form, where the polyphenol molecule, called aglycon, is linked to a sugar group, called glycon.

In these specific forms the polyphenols with the exception of anthocyanins, cannot be absorbed until after their hydrolysis by the intestinal enzymes or colon microflora.  These are a few examples of the many variables to be evaluated.

Life Factor Research therefore applies bioavailability and absorption technology to our nutraceutical products and those we reformulate that are used in the pharmaceutical industry to achieve guaranteed potency and dosage levels. This is essential for individuals taking any form of nutraceutical or prescription as they must be confident of ingesting and absorbing precise amounts for their health. All Life Factor Research formulations and products are prepared with the correct absorption technology. As described above, It is important to understand that absorption is not a “one size fits all” solution for all ingredients and products containing multiple compounds.

To obtain optimum results specific absorption options are necessary. This fits with our synergistic and systematic formulation approach, i.e., making sure that ingredients are combined that work together, are absorbed and work within the organ systems of the body for the intended health support outcome.  One review study that goes more into detail on these considerations is included below for those who want to understand this complex subject more thoroughly.


Bioavailability of nutraceuticals: Role of the food matrix, processing conditions, the gastrointestinal tract, and nanodelivery systems

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