Absorption Technology

Life Factor Research recognizes that applying absorption technology is not a “one size fits all” solution for all ingredients and products containing multiple compounds.

Absorption and Bioavailability: It has been said “you are what you eat” which is not reality, a better way to say it would be “you are what your body can absorb and assimilate”. When it comes to high end nutraceutical products and compounds the joke has been about the expensive urine which sadly has a lot of truth connected to it.

LFR works with a number of technologies that can and are proven through scientific absorption studies to maximize this all important component to good health.

One Step Further…..

Additionally we take it one step further and would maintain that getting a compound past the digestive enzymes and into the bloodstream is not the end all be all that the industry would have you believe…the real game changer is getting these invaluable compounds and formulas past the individual cell walls.this is known a Solubility and is a technology that we are currently preparing to bring to the nutraceutical world for the very first time ever.

Mechanisms of Action: This is simply the ability to prove that what you are saying is actually happening at a scientific level and once again all roads lead to the science which is why we are so closely aligned with the kinds of individuals that can do the in-lab testing to prove beyond doubt how our product does what we are climbing it can and will do.

Delivery Mechanism: How one actually delivers a valuable compound into the body can and does have a tremendous effect on the overall  outcome. This is precisely why we have an assortment of delivery mechanisms for all of our products and sometimes more than one for the same product.

These methods include: Capsules, Tablets, Soft Jells, Powders  Sublingual, Bucosal, Olfactory, Transdermal, Patches, Drinks, Shots, Etc

Proprietary Compounds and Formulas: Because of the team assembled and the relationships that result we are most fortunate to have agreements in place that give us the exclusive world-wide rights to compounds that by their very nature are a semi-technology by themselves. These are products not in the market but well on there way that will be extremely disruptive and highly profitable due to the exclusive nature in which they were conceived

The science of absorption and bioavailability can be complex.  For example the physicochemical properties (chemical structure, solubility, lipophilicity, etc.)  of any nutraceutical formulation must be considered to achieve optimal bioavailability.  Most nutraceuticals are extracted from the natural plant sources and are presented as the crystalline or amorphous powders with high melting points and different water solubilities. Other nutraceuticals such as CLAs and ω‐3/ω‐6 PUFAs are liquid, lipophilic, and water‐insoluble substances. Nutraceuticals are consumed both as the supplements in tablet, capsule, powder and even syrup form.  Molecular weight and the chemical structure of nutraceuticals affect bioavailability parameters such as solubility, lipophilicity, and permeability.

This in turn, influences the bio-accessibility and absorption in the epithelial cells of the intestinal tract.  High bioavailability is the result of a compromise between the solubility and the lipophilicity of biomolecules.  Lipophilic biomolecules have a poor solubility in the GI tract and fluids have a low bio-accessibility.

Hydrophilic biomolecules have a high solubility but are more difficult to pass through the lipophilic bilayer of epithelial cells.  Therefore, some bioactive compounds end up having high solubility but poor cell membrane permeability (e.g., epigallocatechin‐3‐gallate and vitamin C), others have a low solubility and a low cell membrane permeability such as curcumin.  Some possess low solubility but high cell membrane permeability such as resveratrol.  An important example showing the relationship between the structure and the bioavailability is polyphenols. They are found in different plants either in the form of polymers (e.g., proanthocyanidins) or in a glycosylated form, where the polyphenol molecule, called aglycon, is linked to a sugar group, called glycon.

In these specific forms the polyphenols with the exception of anthocyanins, cannot be absorbed until after their hydrolysis by the intestinal enzymes or colon microflora.  These are a few examples of the many variables to be evaluated.

Life Factor Research therefore applies bioavailability and absorption technology to our nutraceutical products and those we reformulate that are used in the pharmaceutical industry to achieve guaranteed potency and dosage levels. This is essential for individuals taking any form of nutraceutical or prescription as they must be confident of ingesting and absorbing precise amounts for their health. All Life Factor Research formulations and products are prepared with the correct absorption technology. As described above, It is important to understand that absorption is not a “one size fits all” solution for all ingredients and products containing multiple compounds.

To obtain optimum results specific absorption options are necessary. This fits with our synergistic and systematic formulation approach, i.e., making sure that ingredients are combined that work together, are absorbed and work within the organ systems of the body for the intended health support outcome.  One review study that goes more into detail on these considerations is included below for those who want to understand this complex subject more thoroughly.


Bioavailability of nutraceuticals: Role of the food matrix, processing conditions, the gastrointestinal tract, and nanodelivery systems

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